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Early Stage Startup


Pioneers in Industrial Enzymes for Lignocellulosic Biomass

Elevator Pitch

We design and market novel enzymatic solutions for the most challenging of industrial conditions to meet our customer specific need.
MetGen is a venture-backed start-up which has invented a disruptive technology to develop industrial enzymes. These enzymes reduce the use of costly energy and chemicals in pulp and paper production and accelerate the path to low cost sugars for the production of biofuels and biochemicals from cellulosic feedstock. MetGen’s tailored enzyme solutions have huge potential to improve the sustainability of chemicals, fuels and paper.


MetGen develops and produces MetZyme®, a new class of highly-active industrial enzymes.

Pulp & Paper Industry:
In the pulp and paper industry, MetGen’s enzyme solution boosts profitability and sustainability. It significantly reduces energy consumption and hence carbon footprint at the refining stage in mechanical pulping, when at the same time improving the process itself and the paper quality.
MetZyme® is particularly suitable for thermo mechanical pulping (TMP) which consume large amounts of electric energy. The enzymes are also used for pitch control of pulp. TMP P&P mill spends average 17 Mln EUR / year for energy in refining only. MetGen solution saves 3 Mln EUR / year for 1 mill. Enzyme cost for mill - 1 Mln. Addressable market (TMP mills in Europe) is estimated around 80 Mln/Eur in sales revenue. Our customers do not require CAPEX to use our product.

Biorefinery and renewable chemicals:
It is evident that the challenges to the economically feasible production of lignocellulosic sugars for biorefineries are complex. It is also unlikely that a ‘one size fits all’ enzymatic solution will be available soon for diverse feedstocks; there are simply too many variables
Currently, the problem of inefficient hydrolysis due to diverse feedstocks and pre-treatments is primarily solved through enzyme overdosing (primarily cellulase). Unfortunately, this practice keeps the entire biofuel process economically unfeasible. It’s not reasonable to expect that there will be one magic cellulase based cocktail which will be able to convert dramatically different feedstocks with equal efficiency.
We suggest that the second most important consideration (after optimizing existing pre-treatment technologies for a particular feedstock) is to optimize the enzymes specifically for the pre-treated lignocellulosic material. MetGen enzymatic solution addition effects on decreasing usage of harsh chemicals and/or excessive heat at biomass pretreatment step. Addition of MetZyme to hydrolysis solution increases fermentable sugar yield by 50% at the same total enzyme dosage.
MetGen’s enzymes are protected by several international patents and more inventions are expected to apply for patent protection.
Our business model is CAPEX light. We outsource high volume fermentation to the leading industrial enzyme contract manufacturers.
MetGen has achieved successful industrial trials with sector leaders in forest and biofuels. Commercial recurring revenues will materialize within the course of 2015
MetGen has agreements with several large European contract manufacturers. This not only assures security of supply, but also enables the optimisation of logistics costs, depending on the customer location
MetGen is currently serving a customer base in the European market and in due time plans to expand into the Latin American and Canadian pulp and paper markets.

Why we are ecofriendly

MetZyme®, the enzymes developed by MetGen, presents a range of environmental benefits across the sectors it serves.

• In pulp and paper, MetZyme® boosts profitability and sustainability by reducing energy consumption and improving paper quality. It significantly reduces energy consumption and hence carbon footprint at the refining stage in mechanical pulping.

• For second-generation biofuels and bio-based chemicals, MetGen’s enzymes contribute to the development of low-cost sugars from cellulosic feedstock. Low-cost sugars are the building blocks for the production of second-generation biofuels and bio-based chemicals, hence enabling a paradigm shift in the chemicals industry by moving away from petroleum feedstock to renewable biomass.
MetZyme has multiple benefits such as lower total enzyme cost, less energy consumption and faster fermentation rates
MetGen’s tailored enzyme solutions have huge potential to improve the sustainability of chemicals, fuels and paper.

Latest News

Recently, MetGen awarded with Horizon 2020 SME grant (1.5 Mln Eur) focusing on acceleration of industrial production of enzymes


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Version History

2015-04-09 08:13:35 - changed tags to 'enzyme, energy saving, pulp&paper, biofuel, biorenewable chemicals, sustainability'

2015-04-09 08:13:11 - changed grantsraised to '> 2 Mln Eur'

2015-04-09 08:13:09 - changed capitalraised to '> 2 Mln Eur'

2015-04-09 08:13:00 - changed pitch to 'We design and market novel enzymatic solutions for the most challenging of industrial conditions to meet our customer...'

2015-04-09 08:12:39 - changed tagline to 'Pioneers in Industrial Enzymes for Lignocellulosic Biomass'


Capital Raised

> 2 Mln Eur

Grants Raised

> 2 Mln Eur




• Sofinnova Partners, an independent venture capital firm based in Paris, France which invests in start-ups, early stage companies, corporate spin-offs and occasionally turnaround situations. Sofinnova Partners invest primarily in life sciences (biopharmaceuticals/biotech, medical devices, industrial biotech) and clean energy.
• Finnish Industry Investment Ltd, a government-owned investment company which promotes Finnish business, employment and economic growth through venture capital and private equity investments. The investment focus is on growth, internationalisation, spin-offs, major industrial investments and sectoral and corporate restructurings.
• Finnvera, who provides financing for the start, growth and internationalisation of enterprise operations and for hedging against export risks. Finnvera is a specialised financing company owned by the State of Finland and it has an official Export Credit Agency (ECA) status.
• Emerald Technology Ventures is a globally-recognised venture capital investor in industrial technologies in the areas of energy, water and advanced materials. Emerald has a strong investor base with many of the largest multinational corporations. The investment focus spans from early stage to growth opportunities that are lead by outstanding entrepreneurs.


Customer list is confidential.
MetGen has relationship with dozen of leading industrial customers in Pulp&Paper and Biofuel sectors


In 2014 MetGen won the Best in BioFuel / BioEnergy category for the Global Cleantech Cluster Association (GCCA) 2014 Later Stage Award
MetGen was named in the prestigious 2013 Global Cleantech 100 list, produced by Cleantech Group, which highlights the most promising cleantech companies that are likely to make the most significant market impact over the next 5-10 years.
• In 2012, MetGen was among the top 25 Cleantech Start-ups from Nordic Cleantech, reaching the top 10 Cleantech Start-ups in the Nordics (Nordic Cleantech Open).
• MetGen was selected as Cleantech Company winner of Eurecan European Venture Contest 2010.

Country of Origin





Alex Michine - CEO

Klara Birikh, PhD - R&D Manager
Harri Niemela - Sales and Marketing Director
Matti Heikkila - Technology Director

Contact Person

Alex Michine, alex@metgen.com


Rakentajantie 26
20780, Kaarina, Finland


enzyme, energy saving, pulp&paper, biofuel, biorenewable chemicals, sustainability